CRC 765/3: Characterization and Optimization and Action Principle: New Architectures, Functions and Applications (SP C06)

The goal of the project is the inhibition of fusion properties of influenza viruses by means of a specific interaction of multivalent ligands with the fusion protein hemagglutinin. By using multivalent ligands the principles of an amplification mechanism will be unravelled. To this end, nanoparticles covered with those ligands will be used. Several methods including imaging techniques will be applied to study the mechanism and the underlying interaction between ligand and hemagglutinin. Strategies for efficient inhibition of virus infection will suggested.