RG 5705: NeuroFlame – Defence and demise of inflamed neurons

Neuroinflammation has emerged as a central unifying theme in a wide range of neurological pathologies. Besides diseases with obvious inflammatory character, like multiple sclerosis, also the course of neurodegenerative, vascular, and traumatic brain diseases proves to be heavily influenced by neuroinflammation. However, despite the urgent need for neuroprotective treatments in all of these conditions, a detailed understanding of how neuroinflammation affects neuronal function and viability is lacking. The mission of NeuroFlame Research Unit is to close this gap in knowledge by gathering thought leaders and methodological experts in the field to explore neuronal defence strategies and injurious pathways, establish causal relationships by experimental interference and work out the sequence of events that determines neuronal outcome in the face of neuroinflammation. This collaborative effort will lay the foundation for the development of new neuroprotective treatments with broad applicability.