RG 5187/1: Generalizing predictive patterns of treatment (non-) response: from specific phobia and obsessive-compulsive disorder to the anxiety spectrum (SP 9)

The objective of subproject 9 (SP9) of DFG Research Unit (RU) 5187 "Towards precision psychotherapy for non-respondent patients: From signatures to predictions to clinical utility" is to compare the neural/psychophysiological signatures of treatment outcome between different anxiety disorders (AD) and related conditions as well as between obsessive-compulsive disorder (OCD) and the anxiety spectrum and test for their degree of generalizability or specificity. We will take advantage of an overlapping neuroimaging and EEG/ECG backbone between several studies. First, we will exploit available retrospective datasets from our group which allow us to apply replication and external validation with the new dataset from subproject 1 of this RU using state-of-the-art machine learning methodology. Second, we will compare treatment-related signatures between ADs from phobic fear to more generalized forms and between OCD and the anxiety spectrum in the new data set. Both group-based analyses as well as single-case predictions with multivariate pattern recognition will be employed.