RG 5151/1: Quantifying Liver Perfusion-Function Relationship in Complex Resection - A Systems Medicine Approach (QuaLiPerF)

Complex, extended liver resections (ePHx) pose a high risk of postoperative liver failure, especially in case of preexisting liver disease. We aim to improve our mechanistic understanding of the interplay between hepatic perfusion and function to an unprecedented level in order to allow individualized functional prediction when planning liver surgeries. We will achieve this goal by integrating systems biology methods and imaging techniques as well as multimodal, longitudinal personalized patient data.